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Medicine that inhibit CYP2D6 activity, for example paroxetine and quinidine, may possibly cause diminished clearance of oxycodone which could lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in an increase in oxycodone Cmax by eleven%, AUC by 13%, and t½ elim.Clients needs to be titrated to ache ai